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. 2018 May 25;8:8119. doi: 10.1038/s41598-018-26459-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ZnR/GPR39 expression is increased in higher grade breast cancer tissue. (A) An array of breast cancer biopsies (http://www.biomax.us/tissue-arrays/Breast/BR1504a) was stained for ZnR/GPR39. Average staining level, above a threshold, in ER negative samples of grade 2 and grade 3 tissues is shown (scale bar shown on image). Representative images of ZnR/GPR39 staining and hematoxylin eosin stain (from the company site) are shown (bottom panel). (B) Analysis of ZnR/GPR39 mRNA level in ER-positive or negative, HER2-normal, breast cancer grade 2 (white) or 3 (grey) tumors (GDS4057 cohort, left panel). Note that a significant increase is seen in ZnR/GPR39 expression in ER-negative grade 3 tumors (p < 0.05 t-test). Right panel shows the analysis of mRNA level of P2XR1 purinergic receptor on the same cohort. (C) Analysis of ZnR/GPR39 mRNA level in ER-positive or negative, breast cancer stage 2 (white) or 3 (grey) tumors (TCGA cohort, p < 0.05, Welch’s t-test).