Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 25;9:2081. doi: 10.1038/s41467-018-04449-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Prolonged expression of reprogramming factors induces poorly differentiated cancers in KC-OSKM chimeric mice. a Sall4, Lin28a, and Ki67 staining in undifferentiated pancreatic cancer induced by Dox treatment for 1 week followed by Dox withdrawal for 1 week in KC-OSKM chimeric mice. Scale bar, 50 μm. b Representative macroscopic image, histology, and Ki67 immunostaining of gastric cancer induced by prolonged transient expression of reprogramming factors in KC-OSKM chimeric mice (Dox On for 2 weeks and then Dox Off for 2 weeks). Scale bars, 100 μm. c Immunotaining for Sall4, Lin28a, and Afp in poorly differentiated gastric cancers in KC-OSKM chimeric mice. Scale bars, 100 μm. d Incidence of Afp, Sall4, and Lin28a expression in poorly differentiated gastric cancers in KC-OSKM chimeric mice. e Histology and immunostaining for SALL4, LIN28A, and LIN28B in human AFP-producing gastric cancers. Scale bar, 100 μm. f Incidence of SALL4-, LIN28A-, and LIN28B-positive cases in human AFP-producing gastric cancers. g Partial activation of ESC-Core and ESC-Myc modules in human gastric cancers expressing AFP or SALL4