Fig. 4.

Identifying transcription factors important for transformation. a Criteria for TFScore. See Methods for a detailed description. b Rank order of transcription factors potentially playing important regulatory roles during cell transformation, based on TFScores (top 50 are shown). For each transcription factor, the relative contribution of 4 criteria to TFScore, and annotated super-enhancer genes are shown. The 20 genes used for validation by siRNA knockdowns (Fig. 5) are shown in blue