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A model to explain the mechanisms by which the tight reciprocal regulation between c-Mos and cyclin B/cdc2 assures CSF arrest and CSF exit. Discontinuous arrows denote different states of the same protein. Continuous arrows represent the direct or indirect effect of one protein on another. Thick arrows signal direction of the pathway in each situation. Mechanisms by which intracellular Ca2+ releases the MAPK-dependent inhibition of APC are unknown. Ub, ubiquitin.
