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. 2018 May 25;8:8102. doi: 10.1038/s41598-018-26496-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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I-BET762 possesses anti-migratory and anti-invasive properties. (A) Scratch wound healing assays showed that 1 μM I-BET762 inhibits migration of BxPC-3 and Panc-1 cells. (B) The distance migrated by BxPC-3 and Panc-1 cells after treatment was quantified. The migrated distance was quantified by measuring the difference at time 0 and 24 h and was normalized to control. (C) I-BET762 at 1 μM inhibits the invasion of BxPC-3 and Panc-1 cells. The invaded PDAC cells were quantified by counting the cells at the bottom of the inserts. (D) I-BET762 at 1 μM significantly inhibits colony formation in BxPC-3 and Panc-1 cells. Colony formation assays were repeated at least three times and were normalized to control. The results of (B,C and D) are expressed as the means ± SD of 3 independent experiments. **P < 0.01.