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. 2018 May 25;8:8102. doi: 10.1038/s41598-018-26496-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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I-BET762 downregulates stem cell factors and inhibits sphere formation in PDAC cells. (A) A single cell suspension of 200 cells in media to was seeded in ultralow adherent 24-well plates. After sphere formation, cells were treated with 1 μM I-BET762 for 14 days. The spheroids were analyzed by light microscopy and imaged. (B) I-BET762 depletes the protein expression of putative stem cell factors in PDAC cells. β-Catenin, Oct-4, Nanog, and BMI-1 were downregulated after 24 h of treatment. The results of (A) are expressed as the means ± SD of 3 independent experiments. **P < 0.01.