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. 2018 May 25;8:8102. doi: 10.1038/s41598-018-26496-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of I-BET762 and gemcitabine (GEM) on PDAC cell lines. (A) Indicated cells were treated with I-BET762 and GEM. CCK-8 analysis showing that the combination of I-BET762 and GEM was more cytotoxic than either compound alone. (B) Indicated cells were treated with 1 μM I-BET762, 5 μM GEM or their combination. Flow cytometry analysis showing that I-BET762 enhances GEM-induced apoptosis.