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. 2018 May 25;8:8102. doi: 10.1038/s41598-018-26496-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antitumor effects of gemcitabine (GEM), I-BET762, and their combination in a pancreatic xenograft mouse model. (A) Tumor volume over time indicating that combination therapy was more effective than either treatment alone. (B) Ki67 staining revealing that both I-BET762 and GEM inhibited the proliferation of xenograft tumor cells and that combined treatment with I-BET762 and GEM showed a greater capacity to inhibit proliferation. (C) TUNEL assay showing that I-BET762 enhanced the apoptosis induced by GEM, which was blocked in Bim-KO cells. (D) I-BET762 had no effect on the AST or ALT levels and did not enhance the AST and ALT increase induced by GEM. Both I-BET762 and GEM had no effects on BUN. The results of (A,B,C and D) are expressed as the means ± SD of 3 independent experiments. *P < 0.05.