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. 2018 May 25;9:2084. doi: 10.1038/s41467-018-04548-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Developmental divergence of ON and OFF receptive fields in primary auditory cortex. a, b Example peri-stimulus time histograms of spiking activity in A1 neurons of young (P15–23; a) and adult (>P60; b) mice responding to pure-tone onset (green) and offset (red). c Single neuron frequency response areas (FRAs) for sound onsets (top) and offsets (middle) in young mouse. Bottom, characteristic frequency (CF) was similar for onset and offset (green and red circles), and FRAs were overlapping (black bar). d Single neuron FRAs for sound onsets (top) and offsets (middle) in adult mouse. Bottom, CFs were segregated for onset and offset (green and red circles), and FRA overlap was limited (black bar). e Relationship between ON and OFF CF for individual A1 neurons in young (blue) and adult (grey) mice. The dashed diagonal line represents a perfect correspondence between ON and OFF CF. f Distribution of the absolute difference between ON and OFF CF for neurons in young (blue) and adult (grey) mice. g FRA overlap in young and adult mice. Receptive field boundaries are largely overlapping early in development (blue) and later become segregated (grey)