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. 2018 May 25;8:8157. doi: 10.1038/s41598-018-26383-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with OCA ameliorates the progression of NASH in MC4R-KO mice. (a) Experimental protocol for evaluation of the effect of OCA on the progression of NASH in MC4R-KO mice. (b) Time course of NAS, fibrosis area, and hCLS number in the liver. (c) Hepatic mRNA expression levels of FXR-regulated gene (Slc51b), inflammatory markers (Tnfa, Emr1 and Ccl2) and fibrogenic factors (Tgfb1 and Col1a1) after 4 and 8 weeks treatment with OCA. ^##p < 0.01 MC4R-WD (pre-treatment) group vs. WT-SD group. ^*p < 0.05, ^**p < 0.01 OCA-treated MC4R-WD group vs. the vehicle-treated MC4R-WD group at each time point. Open square, vehicle-treated MC4R-WD group (pretreatment, n = 10; 4w and 8w, n = 8); closed circle, OCA-treated MC4R-WD group (4w, n = 8; 8w n = 9). WT-SD, n = 7.