Table 1.
Preventive effect of OCA on serological parameters of MC4R-KO fed WD for 24 weeks.
| WT-SD | MC4R-WD | |||
|---|---|---|---|---|
| Vehicle | Vehicle | OCA (3) | OCA (10) | |
| BG (ad lib, mg/dL) | 126.1 ± 3.6 | 146.1 ± 8.7 | 119.1 ± 5.5* | 138.4 ± 9.2 |
| Insulin (ad lib, ng/ml) | 0.8 ± 0.2 | 31.7 ± 6.5## | 35.9 ± 6.7 | 50.7 ± 6.8 |
| TC (mg/dL) | 88.4 ± 3.8 | 337.0 ± 16.0## | 300.0 ± 15.0 | 232.0 ± 8.5** |
| TG (mg/dL) | 112.4 ± 12.6 | 58.0 ± 6.2## | 46.2 ± 8.6 | 47.1 ± 4.7 |
| NEFA (mEq/L) | 1.26 ± 0.06 | 1.07 ± 0.05# | 1.01 ± 0.06 | 0.94 ± 0.06 |
| ALT (U/L) | 29.2 ± 1.0 | 439.6 ± 58.3## | 412.8 ± 43.8 | 160.9 ± 31.2** |
| AST (U/L) | 157.6 ± 13.8 | 381.2 ± 33.9## | 384.6 ± 39.5 | 210.0 ± 25.2** |
WT, wildtype mice; MC4R-KO, melanocortin 4 receptor deficient mice; SD, standard diet; WD, Western diet; OCA, obeticholic acid; BG, blood glucose; TC, total cholesterol; TG, triglyceride; NEFA, non-esterified fatty acid; ALT, alanine aminotransferase; AST, aspartate transaminase. Data are expressed as the mean ± SE. n = 6–10. #p < 0.05, ##p < 0.01 vs. WT-SD group, *p < 0.05, **p < 0.01 vs. vehicle-treated MC4R-WD group.