Fig. 3.

New genetic subgroups of GBM display distinct survival patterns. Kaplan-Meier analysis of GBMs grouped by recurrent alterations identified in this study, including SMARCAL1/ATRX mutation (IDH^WT-ALT) and TERT rearrangement (IDH^WT-TERT^SV). The survival of these new groups are compared to established subgroups of GBM including TERT promoter-mutant (IDH^WT-TERTp^MUT, N = 223) and IDH-mutant GBMs (IDH^MUT-TERT^WT, N = 23), with median overall survivals of 14.74 and 37.08 months, respectively. Patients in the IDH^WT-other GBM subgroup (N = 7) were excluded due to the limited number of patients. The median OS for the IDH^WT-ALT subgroup (N = 17) was 14.9 months, while the IDH^WT-TERT^SV subgroup (N = 16) had an OS of 19.7 months. Compared to the IDH^MUT-TERT^WT GBMs, the IDH^WT-TERTp^MUT (P = 0.0003, HR = 2.867, 95% CI: 1.929 to 4.262), IDH^WT-ALT (P = 0.0281, HR = 2.302, 95% CI: 1.039 to 5.1), and IDH^WT-TERT^SV GBMs (P = 0.0794, HR = 1.982, 95% CI: 0.8878 to 4.427) have poorer survival. Comparison of survival curves done by log-rank (Mantel–Cox) test