Figure 1.

Predicted values of diffusion coefficients (solid black line) based on LDVM as a function of the size r_p calculated for different Drp1 oligomers. The size ranges for different oligomers are indicated by vertical dotted and dashed lines, with the number of Drp1 molecules forming an oligomer shown at the top. The experimental values of diffusion coefficients measured for test probes of increasing size, including GFP (r_p = 2.4 nm) GFP-Drp1 K668E (monomeric Drp1, r_p = 4.7 nm), GFP-Drp1 G363D (dimeric Drp1, r_p = 6.7 nm) and GFP-ferritin (r_p = 9.4 nm) are shown as full black diamonds (for HeLa wt) and empty diamonds (for HeLa Drp1 KO).