Table 2.

Effect of Axc expression in E. coli on the susceptibility towards imipenem and meropenem.

Strain	MIC (mg/L)
	Imipenem		Meropenem
	−IPTG	+IPTG	−IPTG	+IPTG
E. coli_ Axca	0.5	4	1.563	12.5
E. coli_controlb	0.38	N.D.	0.391	0.391
KPCc	>32	>32	>12.5	>12.5

Minimal inhibitory concentrations of imipenem and meropenem for E.coli C43 expressing Axc (E. coli_ Axc), or PPEP-1 (E. coli_control) and Klesbsiella pneumoniae expressing KPC carbapenemase (KPC). N.D: Not detectable. IPTG: isopropyl β-D-1-thiogalactopyranoside.

^aJC107: Escherichia coli C43/pET21B-Axc.

^bJC108:Escherichia coli C43/pET21B/PPEP-1 (Pro-Pro endopeptidase 1).

^cJC113: Carbapenemase-positive Klebsiella pneumonia.