Table 2.

Safety evaluation

Patient no.		Toxicity of HF10	DLT	Evaluation (CTCAE ver 4.0)
Cohort 1	HF-1-02	(−)	(−)	Grade III Neutrophil and Platlet count decrease, Duodenal stenosis, Perforative peritonitis
	HF-1-04	(−)	(−)	Grade II fever, Blood bilirubin increase (stent failure), Interstitial pneumonia (After treatment)
	HF-1-05	(−)	(−)	NA
Cohort 2	HF-2-01	(−)	(−)	Grade III Neutrophil decrease
	HF-2-02	(−)	(−)	Grade III Neutrophil decrease
	HF-2-03	(−)	(−)	Grade III Neutrophil decrease and Grade II ALT increase
Cohort 3	HF-3-01	(−)	(−)	Grade IV Hepatobiliary disorder
	HF-3-02	(−)	(−)	NA
	HF-3-03	(−)	(−)	NA
	HF-3-04	(−)	(−)	Grade III Neutrophil decrease

DLT dose-limiting toxicity