Table 3.
Drug sensitivities in monolayer culture system, tumor spheroids, and multicellular tumor spheroids (MCTSs) of patient-derived cells
| Cells | Spheroid formation | Drug sensitivity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Monolayer culture | Tumor spheroids | MCTS | ||||||||
| 5-FU | Cis | Sor | 5-FU | Cis | Sor | 5-FU | Cis | Sor | ||
| 103209 | Compacted spheroid | ++ | – | – | – | – | – | + | – | + |
| 101509 | Compacted spheroid | + | + | – | + | – | – | + | – | – |
| 116261 | Compacted spheroid | ++ | + | – | – | – | – | – | – | – |
| 8513B | Loosely compacted aggregates | + | – | – | ++ | + | – | – | – | – |
| 51532B | Loosely compacted aggregates | + | + | – | ++ | + | + | + | – | ++ |
| 21612B | Compacted spheroid | + | – | – | – | – | – | – | – | – |
| 35372B | Compacted spheroid | + | – | – | ++ | – | + | + | + | – |
| 27273B | Compacted spheroid | ++ | – | – | + | + | – | + | – | – |
Drug sensitivity of 2D were compared to each other, and drug sensitivity of 3D and MCTS were compared together to each other. -; no drug sensitivity, +; middle of drug sensitivity, ++; high of drug sensitivity
aCis Cisplatin, Sor Sorafenib