Table 1.
Baseline patient characteristics
| Sub-cohorts used for: | ||||
|---|---|---|---|---|
| Main cohort N = 122a |
CCSP & SP-D N = 19a |
Inflammatory proteins N = 15 |
Cell count N = 6 |
|
| Recipient age at transplant, year (Mean ± SD) | 54.1 ± 16.7 | 55.3 ± 15.8 | 57.7 ± 11 | 56.7 ± 16.7 |
| Primary diagnosis | ||||
| Idiopathic pulmonary fibrosis | 53 (43.4%) | 10 (52.6%) | 7 (46.7%) | 5(83.3%) |
| Chronic obstructive pulmonary disease | 23 (18.9%) | 3 (15.8%) | 4 (26.7%) | 0 |
| Cystic fibrosis | 16 (13.1%) | 3 (15.8%) | 3 (20%) | 0 |
| Scleroderma | 6 (4.9%) | 1 (5.3%) | 0 | 0 |
| Chronic Lung Allograft Dysfunction | 5 (4.1%) | 0 | 0 | 0 |
| Sarcoidosis | 4 (3.3%) | 0 | 0 | 0 |
| Bronchiectasis | 4 (3.3%) | 0 | 1 (6.7%) | 0 |
| Alpha-1 antitrypsin deficiency | 3 (2.5%) | 0 | 0 | 0 |
| Langerhans cell histiocytosis | 2 (1.6%) | 1 (5.3%) | 0 | 0 |
| Other | 6 (4.9%) | 1 (5.3%) | 0 | 1 (16.7%) |
| Transplant type | ||||
| Single lung transplantation | 23 (18.9%) | 5 (26.3%) | 5 (33.3%) | 1 (16.7%) |
| Bilateral lung transplantation | 99 (81.1%) | 14 (73.7%) | 10 (66.7%) | 5 (83.3%) |
| Male Gender | 69 (56.6%) | 14 (73.7%) | 9 (60%) | 3 (50%) |
| Number of lung transplants | ||||
| First lung transplant | 116 (95.1%) | 18 (94.7%) | 15 (100%) | 5 (83.3%) |
| Second lung transplant | 6 (4.9%) | 1 (5.3%) | 0 | 1 (16.7%) |
| CLAD status at time of bronchoscopy | ||||
| CLAD | 14 (11.5%) | 7 (36.8%) | 3 (20%) | 1 (16.7%) |
| No CLAD | 108 (88.5%) | 12 (63.2%) | 12 (80%) | 5 (83.3%) |
AR=Acute rejection; n=number; %=percent of samples
aNumber of patients is smaller than number of bronchoscopies