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. 2018 May 25;19:402. doi: 10.1186/s12864-018-4786-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Reduction in symbiont’s ability to produce essential metabolites following removal of specific source metabolites (metabolites predicted to be available to the symbionts in the bacteriocyte) from the simulated host-environment. Only source metabolites whose removal affected at least one species are shown. P, C, H, R and W represent Portiera, Cardinium, Hamiltonella, Rickettsia and Wolbachia, respectively. Square strength color (white to dark green) represent the number of metabolites reduced from the network