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. 2018 May 10;24:3056–3067. doi: 10.12659/MSM.907280

Figure 7.

Figure 7

Overexpression of miR-194 reversed the regulatory function of TRAF6 in LPS-induced NP cells. (A) The relative expression levels of TRAF6 in LPS-induced NP cells transfected with miR-194, TRAF6, or miR-194+TRAF6. (B) Overexpression of miR-194 reversed the TRAF6 induced promotion of Aggrecan and Collagen II expression (P<0.05, P<0.01). (C) Overexpression of TRAF6 rescued the expression of MMP3 and MMP13, which were suppressed by miR-194. (D) Overexpression of TRAF6 rescued the expression of ADAMTS4 and ADAMTS5, which were suppressed by miR-194 (P<0.05, P<0.001). (E) Overexpression of TRAF6 rescued the expression of TNF-α and PGE2 (P<0.01). (F) Overexpression of TRAF6 rescued the expression of IL-1 and IL-6 (P<0.01). ** P<0.01; *** P<0.001.