Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 13;122(11):1555–1564. doi: 10.1161/CIRCRESAHA.117.312174

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

PMC Copyright notice

Figure 1. — Discovery: the role of glycan traits on cardiovascular risk estimates was tested on 3281 samples available. Having identified traits significantly associated with cardiovascular disease risk, we replicated them first, in an independent cohort, validated them in men, and then investigated whether any of these associations could be exclusively explained by any of the individual factors that constitute the ACC/AHA 10-y atherosclerotic cardiovascular disease (ASCVD) risk estimate. The traits that remained associated were then tested for association with presence of subclinical atherosclerosis adjusting for the potential confounders. A subanalysis was performed for the IgG glycan GP18 (% of FA2G2S1 glycan among IgG where FA2G2S1 is the 2-AB mono-sialylated-, galactosylated biantennary N-glycan, core-substituted with fucose), which is strongly negatively correlated with very-low-density lipoprotein (VLDL). ACC indicates American College of Cardiology; AHA, American Heart Association; GP, glycan peak; GlycA, glycoprotein acetylation; ORCADES, Orkney Complex Disease Study; NMR, nuclear magnetic resonance; and UPLC, ultra performance liquid chromatography.