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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Apr 22;28(11):2074–2079. doi: 10.1016/j.bmcl.2018.04.052

Table 2. Hydrogen bonds in FtFabI-benzimidazole complexes.

Interactions Occupancy (%) Interactions Occupancy (%)
Acceptor Donor Acceptor Donor
S-1 Na Y156 OH 67 S-1 N NADH OHb 34
R-1 N Y156 OH 64 R-1 N NADH OH 4
s-2 n Y156 OH 54 S-2 N NADH OH 29
R-2 N Y156 OH 45 R-2 N NADH OH 3
a

N is the nitrogen atom forming the imine group in benzimidazole compounds.

b

OH is the polar hydrogen in the 2′-ribose OH of NADH.