Table I.
Maternal and infant characteristics and associations with BPD
| Characteristics | Whole Preterm cohort (n=80) | No BPD (n=32) | BPD (n=48) | P value |
|---|---|---|---|---|
| Birthweight (g) | 890 [765,1010] | 960 [825,1125] | 863[717,980] | 0.002 |
| Birthweight strata (g) | ||||
| 500 – 749 (n=16) | 660 [590,690] | 690 [655,705] | 640 [578.685] | 0.23 |
| 750 – 999 (n=41) | 890 [825,955] | 853 [800,945] | 895 [835,940] | 0.37 |
| 1000 – 1250 (n=23) | 1125 [905,1265] | 1140 [1050,1260] | 1100 [1040,1220] | 0.61 |
| Gestational age | 27 [26,28] | 27 [26,28] | 26 [25,27] | < 0.01 |
| Male sex | 39 (49%) | 18 (56%) | 21 (41%) | 0.22 |
| Multiple gestation | 14 (18%) | 3 (9%) | 11 (23%) | 0.17 |
| Infant Race | 0.66 | |||
| White | 38 (48%) | 12 (38%) | 26 (54%) | |
| Black | 42 (52%) | 20 (62%) | 22 (46%) | |
| Asian | 0 | 0 | 0 | |
| Other | 0 | 0 | 0 | |
| Ethnicity | 0.46 | |||
| Hispanic or Latino | 1 (13%) | 0 | 1 (2%) | |
| Not Hispanic or Latino | 79 (87%) | 32 (100%) | 47 (98%) | |
| Maternal Smoking | 16 (20%) | 5 (16%) | 11 (23%) | 0.48 |
| Antenatal steroids | 77 (96%) | 32 (100%_ | 45 (94%) | 0.16 |
| Surfactant Replacement Therapy | 80 (100%) | 32 (100%) | 48 (100%) | 0.84 |
| Cesarean section | 55 (69%) | 21 (66%) | 34 (71%) | 0.86 |
| Maternal complications | ||||
| Gestational DM | 4 (5%) | 1 (3%) | 3 (6%) | 0.56 |
| Gestational HTN | 22 (28%) | 12 (38%) | 10 (21%) | 0.28 |
| Prolonged rupture of membranes | 38 (17%) | 15 (15%) | 23 (19%) | 0.12 |
| Chorioamnionitis | 8 (10%) | 4 (13%) | 4 (8%) | 0.51 |
| Preeclampsia | 22 (28%) | 10 (31%) | 12 (25%) | 0.51 |
| Placental Abruption | 14 (18%) | 8 (25%) | 6 (13%) | 0.13 |
| Late onset PH | 12 (15%) | 4 (12.5%) | 8 (17%) | 0.45 |
| Presence of PDA at 36 weeks PMA* | 9 (11%) | 3 (9%) | 6 (13%) | 0.36 |
| Necrotizing enterocolitis | 7 (9%) | 2 (6%) | 5 (10%) | 0.56 |
| ROP threshold (Stage 2 or higher) | 30 (38%) | 6 (19%) | 24 (50%) | 0.02 |
| IVH (Grade 3 or 4) | 9 (11%) | 2 (6%) | 7 (15%) | 0.54 |
| Total oxygen days (NICU) | 87 [46,109] | 38 [18,58] | 100 [88,115] | <0.001 |
| Length of stay (NICU) | 93 [79,114] | 80 [69,100] | 106 [91,120] | <0.001 |
Data are presented as median [interquartile range], or number (Percentage). Data are presented as column percentages
BPD, bronchopulmonary dysplasia; PH, pulmonary hypertension; PDA, patent ductus arteriosus
ROP, retinopathy of prematurity; IVH, intraventricular hemorrhage
*
Presence of PDA, patent ductus arteriosus, at 36 weeks PMA, post-menstrual age.