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. Author manuscript; available in PMC: 2018 Nov 16.
Published in final edited form as: Nature. 2018 May 16;557(7706):570–574. doi: 10.1038/s41586-018-0121-3

Extended Data Figure 6. MXRA8 supports enhanced infection of different CHIKV strains.

Extended Data Figure 6

a. Transduction and expression of different MXRA8 (-1, -2, -3, and -4) isoforms in HeLa cells. Representative data is shown from two experiments. Gray histograms, isotype control mAb; red histograms, anti-MXRA8 mAb. b. Effect of ectopic expression of MXRA8-2 on CHIKV (181/25, AF15561, and LR-2006) infection of A549, HeLa, or 293T cells. Cells were harvested and stained for CHIKV antigen with an anti-E2 antibody. Data are pooled from three experiments and expressed as mean ± SD. Asterisks indicate statistical significance (n = 6; two-tailed t-test with Holm-Sidak multiple comparison correction, ***, P < 0.001; ****, P < 0.0001). c. Transduction and expression of MXRA8-2 in 293T, A549, and HeLa cells. Representative data is shown from two experiments.