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. Author manuscript; available in PMC: 2018 Nov 16.
Published in final edited form as: Nature. 2018 May 16;557(7706):570–574. doi: 10.1038/s41586-018-0121-3

Extended Data Figure 7. Gene-editing of MXRA8 in human cell lines.

Extended Data Figure 7

a. Flow cytometry analysis of MXRA8 expression in human MRC-5, HFF-1, RPE, and Hs 633T cells expressing control or two different MXRA8 sgRNAs. Data are representative of two experiments. b. Gene-edited cells were inoculated with CHIKV (181/25, AF15561, or LR-2006) in HFF-1, RPE, and Hs 633T cells. Cells were stained for viral antigen with an anti-E2 antibody. Data are pooled from two (HFF-1 and Hs 633T) or three (RPE) independent experiments and expressed as mean values ± SD (n = 6; one-way ANOVA with a Dunnett’s multiple comparison test compared to the control, ****, P < 0.0001).