Table 1.
Demographics and image characteristics in patients with CAA and hypertensive ICH.
| CAA-ICH (n=24) | HTN-ICH (n=86) | |
|---|---|---|
| Female, n (%) | 13 (54.2%) | 29 (33.7%) |
| Age, mean (SD), y | 70.9 ± 13.9 | 59.3 ± 13.0§ |
| Hypertension, n (%) | 15 (62.6%) | 81 (94.2%)§ |
| Diabetes | 2 (8.3%) | 21 (24.4%) |
| Dyslipidemia, n (%) | 5 (20.8%) | 31 (36.0%) |
| eGFR, mean (SD), mL/min/1.73m2 | 96.6 ± 31.2 | 95.2 ± 36.0 |
| Previous ischemic stroke, n (%) | 2 (8.3%) | 8 (9.3%) |
| Previous ICH, n (%) | 4 (16.7%) | 3 (3.4%)* |
| LVH, n (%) | 1 (4.8%) | 18 (21.5%) |
| Cerebral microbleed | ||
| Presence of lobar CMB, n (%) | 15 (62.5%) | 0 (0%)§ |
| Presence of deep CMB, n (%) | 0 (0%) | 45 (51.1%)* |
| White matter hyperintensity | ||
| Fazekas scale ≥ 2, n(%) | 17 (70.8%) | 55 (64.0%) |
| Volume, median (IQR), mL | 19.5 (3.5-27.2) | 6.2 (1.9-18.9) |
| Cortical superficial siderosis, n (%) | 4 (16.7%) | 1 (1.2%)* |
| Enlarged perivascular space (≥20) | ||
| Centrum Semiovale, n (%) | 9 (37.5%) | 23 (26.7%) |
| Basal ganglia, n (%) | 6 (25%) | 16 (18.6%) |
| Presence of any lacune, n (%) | 10 (41.7%) | 23 (26.7%) |
| Presence of lobar lacune, n (%) | 7 (29.2%) | 10 (11.6%)* |
| Lobar lacune count, median (IQR) | 0 (0-1) | 0 (0-0) * |
| Presence of deep lacune, n (%) | 4 (16.7%) | 17 (19.8%) |
| Deep lacune count, median (IQR) | 0 (0-0) | 0 (0-0) |
*
P-value <0.05,
§
P-value < 0.001, all other comparisons not significant.
CAA: Cerebral amyloid angiopathy; CMB: Cerebral microbleed; eGFR: Estimated glomerular filtration rate;
HTN: Hypertension; ICH: Intracerebral hemorrhage; LVH: Left ventricular hypertrophy