Table 2.

Unadjusted associations between demographic, anthropometric, and medical characteristics and mosaic loss of chromosome Y

	β	95% CI Lo	95% CI Up	p-value
Demographic, Lifestyle, and
Anthropometric Characteristics
Age, years	−0.0003	−0.0007	0.0001	0.09
Body mass index (BMI), kg/m²	0.0001	−0.0004	0.0007	0.63
Smoking Status
Never	Ref
Former	−0.0039	−0.0082	0.0003	0.07
Current	−0.0059	−0.0124	0.0006	0.07
Smoking pack-years	−0.00010	−0.00017	−0.00003	3.50E-03	^*
Alcohol intake, drinks per week	−0.00008	−0.00025	0.00009	0.34
Education
Less than High School	0.0007	−0.0052	0.0067	0.81
High School / GED	Ref
Vocational / College	−0.0031	−0.0078	0.0016	0.20
Graduate School	−0.0031	−0.0090	0.0028	0.31
Life Occupation
Professional, technical, managerial, administrative	Ref
Sales/clerical	0.0022	−0.0043	0.0086	0.51
Skilled trader worker	0.0027	−0.0019	0.0073	0.25
Operator/laborer	−0.0019	−0.0169	0.0132	0.81
Farming	0.0166	−0.0425	0.0757	0.58
Other	0.0004	−0.0065	0.0072	0.92
Clinic
Winston-Salem (Forsyth County), NC	Ref
Sacramento, CA	−0.0012	−0.0059	0.0035	0.62
Pittsburgh, PA	0.0026	−0.0022	0.0074	0.29
Medical History and Characteristics
Ever diagnosed with any cancer
No	Ref
Yes	−0.0028	−0.0083	0.0028	0.33
History of respiratory disease (COPD, asthma, bronchitis, emphysema)
No	Ref
Yes	−0.0015	−0.0064	0.0035	0.55
LDL Cholesterol, mg/dL	−0.00001	−0.00003	0.00001	0.40
HDL Cholesterol, mg/dL	−0.00003	−0.00019	0.00012	0.67
Diabetes Status
Normal	Ref
Impaired Fasting Glucose	0.0033	−0.0022	0.0086	0.24
New Diabetes	0.0035	−0.0032	0.0101	0.30
Existing Diabetes	−0.0002	−0.0085	0.0081	0.96

p-values <0.05 were considered statistically significant. Separate unadjusted linear regression models were used for each variable. The outcome was the fluorescent signal intensity (median log-R ratio (mLRR)) of a male-specific region of ChrY: 7502455–21979204 measured using Illumina 370CNV-Duo genotyping arrays. Decreased mLRR reflects greater mosaic loss of chromosome Y (mLOY) in a population of leukocytes.