Table 5.
Evaluation of Hemolysis of Rabbit Erythrocytes (%) in the Presence of AMA–NEO Conjugates (100 µM)a
| compound | % hemolysis |
|---|---|
| Triton X-100 | 100.0 |
| NEO | 7.0 ± 0.4 |
| DMSO | 4.0 ± 0.1 |
| AMA | 10.0 ± 4.6 |
| 1 | 4.0 ± 0.1 |
| 2 | 10.0 ± 0.2 |
| 3 | 4.0 ± 0.8 |
| 4 | 4.0 ± 0.1 |
| 5 | 5.0 ± 1.2 |
| 6 | 4.0 ± 0.9 |
| 7 | 5.0 ± 0.4 |
| 8 | 5.0 ± 1.7 |
| 9 | 4.0 ± 0.3 |
| 10 | 4.0 ± 0.6 |
| 11 | 5.0 ± 0.8 |
| 12 | 5.0 ± 0.2 |
a
Red blood cells were incubated with each test compound at 37 °C for 1 h. Experiments were performed in triplicate, and the results are expressed as the average percent hemolysis relative to the positive control (Triton X-100).