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. Author manuscript; available in PMC: 2018 May 27.
Published in final edited form as: Cell Rep. 2018 Jan 30;22(5):1250–1262. doi: 10.1016/j.celrep.2018.01.013

Figure 2. Traf6 Deletion Diminishes the Self-Renewal of HSC.

Figure 2

(A) Outline of competitive BM transplantations using VavCre+ or Traf6−/−VavCre+ mice.

(B) Representative flow cytometric analysis of donor-derived (CD45.2+) and competitor-derived (CD45.1+) PB from recipient mice after competitive transplantation using VavCre+ or Traf6−/−VavCre+ BM cells.

(C) Summary of donor-derived PB proportions at the indicated time points after competitive transplantation using VavCre+ or Traf6−/−VavCre+ BM cells (n = 7 per group).

(D) Proportion of donor-derived VavCre+ or Traf6−/−VavCre+ myeloid (CD11b+) and lymphoid (CD3+ and B220+) proportions at the indicated time following competitive transplantation (n = 7 per group).

(E) Summary of donor-derived BM HSPC proportions at 5 months after competitive transplantation using VavCre+ or Traf6−/−VavCre+ BM cells (n = 7 per group).

*p < 0.05. Data are represented as mean ± SEM.