Table 3. Active site of convergently related peptidases.
| Species | Gene | Protein | Nucleophilea | General base | Other active site residues |
|---|---|---|---|---|---|
| Pigs | BLMH | Bleomycin hydrolase | Cys73 | His372 | Asn396 |
| AFG3L2 | AFG3-like protein 2 | Glu575 | His574 | Asp649 | |
| HTRA4 | Serine protease HTRA4 | Ser326 | His218, | Asp248 | |
| CAPN7 | Calpain-7 | Cys290 | His458 | Asn478 | |
| Humans | OTUD5 | OTU domain-containing protein 5 | Ser224 | His334 | Asp221 |
| SENP6 | Sentrin-specific protease 6 | Cys1030 | His765 | Asp917 | |
| USP14 | Ubiquitin carboxyl-terminal hydrolase 14 | Cys114 | His435 | ||
| LONP1 | Lon protease homolog, mitochondrial | Ser855 | Lys898 |
Notes.
a
The number following an amino acid represents the position of the amino acid in the protein.