Example of invasive ductal carcinoma (grade 3/3) with high RS (RS = 34) detected in a 58-year-old female. a) DCE-MRI demonstrates a 17 mm right breast mass at 1 o'clock, 114 mm from the nipple. On DWI, the lesion exhibits b) high signal intensity on b = 800 s/mm2 diffusion-weighted image with CNR = 4.6 (lesion ROI contour is shown), and c) very low ADC (ADCmean = 0.79 × 10−3 mm2/s). For CNR calculation, d) normal fibroglandular tissue was identified on DCE-MRI at a corresponding slice level in the contralateral breast, e) an ROI was defined on the b = 0 s/mm2 image, where breast tissue is most visible, to cover the largest tissue area possible, f) which then propagated to the b = 800 s/mm2 image to measure the mean DWI signal intensity within the ROI.