Table 3.
Associations between DWI measurements and pathologic biomarkers.
| Nottingham Grade* | Ki-67 Status† | 21-Gene Recurrence Score* | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
||||||||
| Variable | OR‡ | (95% CI) | Adj. P- value§ |
OR‡ | (95% CI) | Adj. P- value§ |
OR‡ | (95% CI) | Adj. P- value§ |
|
| ADC | ||||||||||
| Mean | 0.61 | (0.42–0.88) | 0.044 | 0.83 | (0.53–1.31) | 0.78 | 0.92 | (0.63–1.34) | 0.84 | |
| SD | 0.74 | (0.51–1.07) | 0.27 | 1.15 | (0.75–1.76) | 0.80 | 0.95 | (0.66–1.37) | 0.85 | |
| Min | 0.72 | (0.50–1.03) | 0.22 | 0.87 | (0.53–1.44) | 0.80 | 1.05 | (0.72–1.53) | 0.85 | |
| Max | 0.64 | (0.44–0.94) | 0.082 | 0.99 | (0.64–1.53) | 0.95 | 0.90 | (0.62–1.31) | 0.80 | |
| DWI CNR | 1.76 | (1.21–2.57) | 0.026 | 2.55 | (1.37–4.76) | 0.026 | 1.25 | (0.85–1.83) | 0.56 | |
Abbreviations: ADC = apparent diffusion coefficient; DWI = diffusion weighted imaging; CNR = contrast-to-noise ratio, OR = odds ratio, CI = confidence interval, SD = standard deviation.
*
Ordinal logistic regression with Nottingham grade or Oncotype DX Recurrence Score as the dependent variable;
†
Binary logistic regression with Ki-67 ≥14% as the dependent variable;
‡
Odds ratio per 1-SD increase in ADC or CNR;
§
Wald-test p-value from logistic regression, adjusted for multiple comparisons (15 in total) using the Benjamini and Hochberg procedure to control the false discovery rate at ≤5%.