Table 3.

Between-country (referent: US) comparison of hazard risk of mortality with associated 95% confidence intervals (CI) in patients grouped by clinical features. Unadjusted (uHR) and adjusted (aHR) hazard ratios were estimated using Cox proportional hazards model stratified by year of diagnosis.

Variables	uHR (95% CI) (US=referent)	p	aHR* (95% CI) (US=referent)	p
Between country	0.86 (0.79, 0.94)	0.0002	0.77 (0.71, 0.84)	<0.0001
Sex
Female	0.89 (0.79, 1.00)	0.051	0.76 (0.68, 0.86)	<0.0001
Male	0.83 (0.74, 0.92)	0.0006	0.77 (0.68, 0.87)	<0.0001
Age at diagnosis, years
0 to 9	0.81 (0.70, 0.93)	0.003	0.75 (0.65, 0.87)	0.0001
10 to 14	0.86 (0.70, 1.06)	0.153	0.86 (0.70, 1.06)	0.159
15 to 24	0.88 (0.79, 0.99)	0.031	0.75 (0.66, 0.84)	<0.0001
Tumor Count
1	0.86 (0.79, 0.94)	0.0007	0.79 (0.72, 0.86)	<0.0001
≥2	0.62 (0.47, 0.81)	0.0007	0.58 (0.42, 0.80)	0.001
AML subtype
APL	0.76 (0.52, 1.10)	0.151	0.77 (0.53, 1.12)	0.170
AEL	0.70 (0.32, 1.55)	0.382	1.00 (0.44, 2.26)	0.991
AML-NOS	0.84 (0.76, 0.93)	0.0007	0.77 (0.70, 0.86)	<0.0001
AMML	0.84 (0.64, 1.11)	0.227	0.97 (0.73, 1.29)	0.813
AML inv(16)	2.21 (0.81, 5.98)	0.119	1.81 (0.61, 5.34)	0.089
AML, minimal differentiation	0.37 (0.18, 0.77)	0.008	0.54 (0.25, 1.17)	0.119
AML without maturation	0.39 (0.21, 0.73)	0.003	0.38 (0.20, 0.74)	0.005
AML with maturation	0.40 (0.25, 0.65)	0.0003	0.52 (0.31, 0.86)	0.012
AMKL	0.77 (0.53, 1.11)	0.163	0.71 (0.49, 1.04)	0.081
Other	1.24 (0.70, 2.18)	0.464	1.49 (0.84, 2.66)	0.173

^*As an example, multivariable stratified proportional hazards model for males included age at diagnosis, tumor count, AML subtype, and regional deprivation; multivariable stratified proportional hazards model for APL patients included sex, age at diagnosis, tumor count, and regional deprivation.