In unilaterally nephrectomized rats fed a high salt diet (4% NaCl), Carlstrom and colleagues found that oral administration of sodium nitrate provides significant protection against salt-induced increases in mean arterial pressure (as measured by radioltelemetry) [69].
UNX, unilateral nephrectomy; HS, high salt diet; Nitrate-low, dietary supplementation with a low amount of nitrate (approximately 0.0025 parts nitrate by weight for every 1 part added salt by weight); Nitrate-high, dietary supplementation with a higher amount of nitrate (approximately 0.025 parts nitrate by weight for every 1 part added salt by weight). Values are means ± SEM. *p < 0.05.
Adapted from Carlstrom et al., with permission [69].