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The effects of Abx on 24,25D and 25D occur via different pathways.
| Genotype | Metabolite/Hormone | Effect of Abx |
|---|---|---|
| WT | Vitamin D | variable |
| 25D | ↑ | |
| 24,25D | ↑ | |
| PTH | − | |
| FGF23 | ↑ | |
| Cyp27B1 KO | Vitamin D | − |
| 25D | ↓ | |
| 24,25D | − | |
| PTH | ↓ | |
| FGF23 | ↑ | |
| VDR KO | Vitamin D | ↑ |
| 25D | ↑ | |
| 24,25D | − | |
| PTH | ↑ | |
| FGF23 | − |
Change in vitamin D; 25D; 24,25D; FGF23, and PTH in response to Abx. ↑ indicates increased, ↓ indicates decreased, − indicates no significant change from water.
