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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2018 Apr 23;121:9–19. doi: 10.1016/j.freeradbiomed.2018.04.570

Figure 6. Temporal induction of nuclear γH2AX foci in ara-C exposed DRG neurons.

Figure 6

Representative images of time dependent formation of nuclear γH2AX foci during ara-C exposure of DRG neurons are shown (A). DRG neurons are identified by NF200 (red) and γH2AX foci are observed in green; sparse foci emerge by 12 h with density increasing in the course of 72 h ara-C exposure (scale bar = 20 µm). B) Percent of γH2AX positive nuclei increased over time with positive DRGs reaching ~35%, 75% and 95% by 24 h, 48 h and 72 h, respectively. Data are obtained from three independent biological experiments and presented as mean±SEM percent of γH2AX positive nuclei versus time.