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. Author manuscript; available in PMC: 2018 May 28.
Published in final edited form as: J Chem Inf Model. 2017 Oct 13;57(11):2657–2671. doi: 10.1021/acs.jcim.7b00216

Figure 1. Schematic diagram of a systems pharmacology infrastructure for identification of new targets and anticancer indications of natural products.

Figure 1

(A) Re-construction of drug-target network for natural products; (B) Building predictive network models via bSDTNBI for systematic prediction of new targets of natural products; (C) Performing network analyses for validating the new predicted drug-target interactions and for identifying testable hypothesis of new therapeutic effects of natural products; (D) Building the statistical network models for prioritizing new anticancer indication via integration of the computationally predicted (B) and known drug-target interaction network of natural products into the curated cancer-associated genes (proteins).