Table 2.
Genes containing SNPs notionally statistically significant (p<1 × 10−6) identified in the discovery cohort
| Single nucleotide polymorphisms identified | Lowest p value in discovery cohort | |
|---|---|---|
| Peak cortisol <500 nmol/L | ||
| GJA8 (chromosome1) | rs201161441, rs6657114,*†‡ rs6671502 | 1·69 × 10−22 |
| TRPA1 (chromosome 8) | rs75470088† | 5·04 × 10−7 |
| PDGFD (chromosome 11) | rs7116655† | 8·14 × 10−7 |
| Peak cortisol <350 nmol/L | ||
| PDGFD (chromosome 11) | rs361283, rs361284, rs590216,* rs603781,* rs591118,† rs589796, rs2515080, rs684212, rs517401, rs671851, rs2515083, rs620426, rs619954, rs574494, rs619114, rs618648, rs5794293, rs623031 | 5·80 × 10−8 |
| KRT8P9 (chromosome 15) | rs111566682† | 2·32 × 10−7 |
| PSMD3 (chromosome 17) | rs9912981, rs3859188, rs71355433, rs7222556, rs9916279,*† rs8080546, rs11654706, rs11078932, rs58212353, rs2012 | 4·37 × 10−7 |
| CSF3 (chromosome 17) | rs2827† | 4·48 × 10−7 |
| MED24 (chromosome 17) | rs11555254,* rs2302778, rs7503939, rs17850739,*† rs72834789 | 4·02 × 10−7 |
| Peak continuous cortisol | ||
| LRP1B (chromosome 2) | rs142320277† | 5·23 × 10−8 |
| GBA3 (chromosome 4) | rs111863753† | 7·75 × 10−7 |
| HMGN3 (chromosome 6) | rs13220233† | 2·88 × 10−7 |
| PDE7B (chromosome 6) | rs149647891† | 6·43 × 10−7 |
| SCGN (chromosome 6) | rs5875060† | 7·62 × 10−8 |
| ANKS1B (chromosome 12) | rs191087489, rs143638033, rs142161979† | 8·98 × 10−9 |
| ELSPBP1 (chromosome 19) | rs137939366† | 3·05 × 10−7 |
| Baseline continuous cortisol | ||
| NOS1 (chromosome 12) | rs12815584, rs77562913, rs76830467,† rs75992652, rs34406980, rs150941488 | 3·00 × 10−7 |
| IGH (chromosome 14) | rs201541519† | 3·02 × 10−7 |
| SLC2A10 (chromosome 20) | rs117420762† | 3·12 × 10−7 |
| BCL2L13 (chromosome 22) | rs149352662, rs189673743, rs140179402† | 2·00 × 10−8 |
*
SNPs identified by genotype rather than imputation.
†
Corresponds to the lowest p value.
‡
Probable artifact after review of Manhattan plots.