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. 2018 Jun;188(6):1389–1405. doi: 10.1016/j.ajpath.2018.02.006

Figure 4.

Figure 4

β-Catenin–driven transcription was sensitive to JQ1 inhibition. A:Rgn gene expression was significantly reduced in JQ1-injected mice compared with vehicle-injected controls after partial hepatectomy (PHx). B:Lect2 gene expression was significantly reduced in JQ1-injected mice after PHx. C: Expression of Axin2 tended to be lower in JQ1-injected mice after PHx. D: No change in the gene expression of Ctnnb1 was observed in JQ1-injected mice. E: HepG2 cells transfected with a T-cell factor (TCF)/LEF luciferase reporter and treated with JQ1 for 24 hours showed a dose-dependent decrease in reporter activity after JQ1 treatment. F: HepG2 cells transfected with a p65 luciferase reporter and treated with JQ1 for 24 hours showed a reduction of reporter activity after treatment with 1 μm of JQ1. Data are pooled results. Data are expressed as means + SD. n = 3 independent experiments (A–F). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001 (one-way analysis of variance).