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. 2018 Jun;188(6):1389–1405. doi: 10.1016/j.ajpath.2018.02.006

Figure 6.

Figure 6

Induction of liver regeneration in JQ1-injected animals 72 hours after partial hepatectomy (PHx). A: Schematic of experimental design, with a 50 mg/kg JQ1 injection (or vehicle injection) 2 hours after PHx and harvest at 72 hours after PHx. B: Serum aspartate aminotransferase (AST) levels normalized in both JQ1- and vehicle-injected mice 72 hours after PHx. C: Proliferating cell nuclear antigen (PCNA) staining revealed robust hepatocyte proliferation in both vehicle- and JQ1-injected mice 72 hours after PHx, and Cyclin D1 staining was present in hepatocytes in both vehicle- and JQ1-injected animals 72 hours after PHx. D: Up-regulation of Ccnd1 gene expression was present in both vehicle- and JQ1-injected animals 72 hours after PHx. Data are expressed as means ± SD. ∗P < 0.05 (one-way analysis of variance). Scale bars = 50 μm.