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. 2018 Jun;188(6):1389–1405. doi: 10.1016/j.ajpath.2018.02.006

Figure 9.

Figure 9

Bromodomain and extraterminal inhibition reduced Wnt/β-catenin signaling in the zebrafish acetaminophen (APAP)-induced injury model. A: Scheme illustrating the periods of APAP and JQ1 treatments and analysis stage (arrow). B: Confocal images showing the hepatic expression of OTM:d2EGFP (green, T-cell factor/Lef reporter activity) in regenerating larvae at 12 hours of recovery (R12h). Dashed lines outline the liver. C: Quantification of OTM:d2EGFP expression in the regenerating larvae treated with dimethyl sulfoxide (DMSO) or JQ1, as shown in B. Data are expressed as means ± SEM. ∗P < 0.05 (t-test). Scale bar = 100 μm. CTCF, corrected total cell fluorescence; dpf, days after fertilization.