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. 2018 Jun;188(6):1334–1344. doi: 10.1016/j.ajpath.2018.02.009

Figure 4.

Figure 4

Human choroid plexus tumors display increased Myc expression correlating with increased proliferation. A: Myc staining in control choroid plexus (top), choroid plexus papilloma (CPP; middle), and choroid plexus carcinoma (CPC; bottom) from patients. Arrowheads indicate Myc-positive cells. B: Quantification of percentage of Myc-positive staining epithelial cells in control choroid plexus, CPP, and CPC samples. C: Representative images showing Myc and Ki-67 staining in control choroid plexus (top), CPC-expressing Myc (middle), and CPC not expressing Myc (bottom) from human patients. Black arrowheads indicate Myc-positive cells; white arrowheads indicate Ki-67–positive cells. D: Ki-67 levels in the Myc-expressing CPC sample are significantly higher than in either the Myc-negative CPC sample or the control samples. Each data point represents one field of view from a single sample. Data are expressed as means ± SEM (B and D). ∗P < 0.05, ∗∗∗∗P < 0.0001 (Welch corrected t-test). Scale bars = 20 μm (A and C).