Figure 2.

Glucose-stimulated insulin secretion (Mean +/− SEM) is inhibited following 3 days of metformin exposure. Set of 20 islets were incubated in 3 mM glucose (a) or 28 mM glucose (b) following metformin treatment at different concentrations for 3 days. N = 5 replicates for each condition conducted in three separate trials using islets from five different mice. #P < 0.10, ^∗P < 0.05, ^∗∗P < 0.01.