Table 4.
IC50 values (nM) of 8 representative compounds as ERα antagonist from natural products and their binding affinity evaluated by Discovery Studio 2016.
| Chemical | IC50 (nM) | -CDOCKER_ENERGY | -CDOCKER_INTERACTION_ENERGY |
|---|---|---|---|
| Estradiol | 7.38 ± 0.80 | 32.60 | 42.1106 |
| Genistein | 29.38 ± 6.13 | 31.63 | 45.9033 |
| Daidzein | 107.62 ± 9.38 | 38.321 | 42.813 |
| Phloretin | 74.55 ± 24.24 | 44.56 | 49.7287 |
| Ellagic acid | 62.61 ± 9.34 | 27.54 | 40.3217 |
| EGCG | 66.01 ± 11.59 | 46.72 | 64.262 |
| Ursolic acid | 977.38 ± 125.30 | −65.38 | 24.1527 |
| Kaempferol | 316.67 ± 14.33 | 30.31 | 41.5717 |
| Naringenin | 967.54 ± 70.95 | 30.08 | 38.021 |