Table 3.
Genetic model analyses of the association between the SNPs and DKD with adjustment for age and gender.
| Genetic models | Genotypes | DKD | DM | Without adjustment | With adjustment | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |||||
| rs3752462 | Additive | TT | 150 (49.5%) | 227 (62.4%) | 1# | 0.004∗ | 1# | 0.005∗ |
| TC | 128 (42.2%) | 115 (31.6%) | 1.684 (1.216–2.332) | 1.649 (1.187–2.290) | ||||
| CC | 25 (8.3%) | 22 (6.0%) | 1.720 (0.935–3.162) | 1.817 (0.980–3.367) | ||||
| Dominant | TT | 150 (49.5%) | 227 (62.4%) | 1# | 0.001∗,∆ | 1# | 0.001∗,∆ | |
| TC + CC | 153 (50.5%) | 137 (37.6%) | 1.690 (1.240–2.303) | 1.675 (1.225–2.289) | ||||
| Recessive | TT + TC | 278 (91.8%) | 342 (94.0%) | 1# | 0.269 | 1# | 0.193 | |
| CC | 25 (8.2%) | 22 (6.0%) | 1.398 (0.772–2.533) | 1.493 (0.817–2.728) | ||||
|
| ||||||||
| rs136161 | Additive | CC | 180 (59.4%) | 213 (58.5%) | 1# | 0.944 | 1# | 0.901 |
| CG | 104 (34.3%) | 126 (34.6%) | 0.977 (0.704–1.354) | 1.011 (0.726–1.407) | ||||
| GG | 19 (6.3%) | 25 (6.9%) | 0.899 (0.480–1.686) | 0.869 (0.460–1.644) | ||||
| Dominant | CC | 180 (59.4%) | 213 (58.5%) | 1# | 0.816 | 1# | 0.933 | |
| CG + GG | 123 (40.6%) | 151 (41.5%) | 0.964 (0.707–1.314) | 0.987 (0.721–1.350) | ||||
| Recessive | CC + CG | 284 (93.7%) | 339 (93.1%) | 1# | 0.757 | 1# | 0.652 | |
| GG | 19 (6.3%) | 25 (6.9%) | 0.907 (0.489–1.681) | 0.866 (0.463–1.618) | ||||
Abbreviations: ORs, odds ratios; CI, confidence interval. #Reference category (odds ratio, 1.0); ∗P value < 0.05; ∆ indicates statistical significance by Holm-Bonferroni correction.