Table 3.

Effect of time-specific adherence on study outcomes.

		Not Adjusted for Covariates		Adjusted for Covariates
	N	Estimate (95% CI)	p-alue	Estimate (95% CI)	p-value
PS
6 months	501	−0.39 (−1.78, 1.01)	0.584	−0.61 (−2.05, 0.83)	0.405
1 year	544	−0.66 (−1.92, 0.60)	0.307	−0.81 (−2.11, 0.48)	0.218
2 years	331	−0.95 (−2.27, 0.37)	0.158	−0.83 (−2.24, 0.59)	0.250
3 years	247	−0.82 (−2.78, 1.14)	0.408	−0.49 (−2.52, 1.54)	0.633
PHQ-9
6 months	538	−0.94 (−2.19, 0.31)	0.140	−0.86 (−2.17, 0.45)	0.198
1 year	590	−0.50 (−1.70, 0.70)	0.413	−0.49 (−1.73, 0.75)	0.441
2 years	363	0.10 (−1.21, 1.41)	0.877	0.70 (−0.68, 2.07)	0.319
3 years	256	−2.20 (−3.70, −0.69)	0.004*	−1.95 (−3.50, −0.39)	0.014*
EQ-5D
6 months	567	0.01 (−0.03, 0.06)	0.590	0.01 (−0.04, 0.06)	0.746
1 year	623	0.04 (0.00, 0.08)	0.078	0.04 (0.00, 0.08)	0.075
2 years	371	−0.01 (−0.05, 0.03)	0.649	−0.02 (−0.06, 0.03)	0.452
3 years	259	0.01 (−0.04, 0.07)	0.654	0.00 (−0.06, 0.06)	0.967
T25FW
6 months	593	0.07 (−0.36, 0.49)	0.753	0.11 (−0.29, 0.51)	0.584
1 year	662	0.22 (−0.11, 0.54)	0.188	0.26 (−0.05, 0.58)	0.097
2 years	412	−0.08 (−0.41, 0.25)	0.645	−0.05 (−0.37, 0.28)	0.764
3 years	297	0.15 (−0.28, 0.57)	0.500	0.14 (−0.27, 0.54)	0.514

For outcomes at 6 months, 1 year, 2 years, 3 years, the beta estimates are for adherence at 6 months, 1 year, 2 years, and 3 years, respectively. PS: Performance Scales; PHQ-9: Patient Health Questionnaire 9; EQ5D: European Quality of Life 5 Dimensions; T25FW: Timed 25-foot walk; CI: confidence interval.