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. 2018 May 25;4(2):2055217318778610. doi: 10.1177/2055217318778610

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Estimated number of neT2 lesions at age 20 years, age 30 years and in the overall population in the FREEDOMS, FREEDOMS II and TRANSFORMS trials. A ratio <1 between fingolimod 0.5 mg and control groups signifies a treatment effect in favor of fingolimod. ^¥Values for patients at age 20 or 30 years are based on a statistical model using all data in the ITT population. N = patients in ITT, n = patients with available data. Control refers to placebo for the FREEDOMS and FREEDOMS II trials, and IFN β-1a for the TRANSFORMS trial. Youngest and young MS patients refer to the estimates at age 20 and 30 years, respectively, in all three studies. CI: confidence interval; IFN β-1a: interferon beta-1a; ITT: intent-to-treat; MS: multiple sclerosis; neT2: new/newly enlarging T2.