Table 1.
Demographic and baseline disease characteristics of patients at age ≤20 years, ≤30 years and the overall population.
| FREEDOMS | FREEDOMS II | TRANSFORMS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Age ≤20 years n = 28 |
Age ≤30 years n = 325 |
Overall population N = 1272 |
Age ≤20 years n = 17 |
Age ≤30 years n = 150 |
Overall population N = 1083 |
Age ≤20 years n = 40 |
Age ≤30 years n = 355 |
Overall population N = 1292 |
|
| Demographics | |||||||||
| Age, years | 19.0 ± 0.84 | 25.8 ± 3.33 | 37.1 ± 8.76 | 19.5 ± 0.80 | 25.9 ± 3.39 | 40.5 ± 8.58 | 19.2 ± 0.83 | 25.5 ± 3.39 | 36.2 ± 8.5 |
| Female, n (%) | 22 (78.6%) |
217 (66.8%) | 889 (69.9%) | 12 (70.6%) |
113 (75.3%) | 844 (77.9%) | 34 (85.0%) |
246 (69.3%) |
870 (67.3%) |
| Baseline disease characteristics | |||||||||
| Disease durationsince onset ofsymptoms, years,median (range) | 2.1 (0–9) |
3.4 (0–18) |
6.7 (0–37) |
2.4 (0–10) |
4.9 (0–18) |
8.9 (0–50) |
2.2 (0.3–8.4) |
3.7 (0.2–16.5) |
5.9 (0–40) |
| EDSS score | 2.0 ± 1.38 | 1.86 ± 1.22 | 2.4 ± 1.32 | 1.74 ± 1.06 | 1.88 ± 1.13 | 2.4 ± 1.32 | 1.74 ± 1.11 | 1.73 ± 1.14 | 2.2 ± 1.3 |
| Relapses in theprevious year | 1.6 ± 0.74 | 1.6 ± 0.88 | 1.5 ± 0.77 | 1.5 ± 0.72 | 1.6 ± 0.96 | 1.5 ± 0.96 | 1.7 ± 1.07 | 1.65 ± 0.94 | 1.5 ± 0.97 |
| Number of Gd+ T1lesions | 1.7 ± 3.11 | 2.7 ± 7.2 | 1.6 ± 4.53 | 5.4 ± 10.83 | 2.6 ± 5.62 | 1.3 ± 3.41 | 1.6 ± 4.63 | 2.0 ± 5.8 | 1.2 ± 3.57 |
| Volume of T2lesions, mm3 | 7432.64 ± 8961.86 |
6140.69 ± 7802.09 |
6374.6 ± 7759.71 |
4468.7 ± 3764.22 |
5470.95 ± 6391.42 |
5319.8 ± 7708.45 |
3668.3 ± 3816.07 |
4723.62 ± 6129.61 |
5059.5 ± 6116.41 |
Data presented are mean ± standard deviation unless otherwise specified.
EDSS: Expanded Disability Status Scale; Gd+: gadolinium-enhancing.