JI130 inhibits tumor growth in xenograft model.
A, MIA PaCa-2 cells were implanted in 28-day-old nude mice. Mice were treated with JI130 at a concentration of 50 mg/kg body weight 5 days/week for a total of 3 weeks. B, tumor volume of the mice treated with JI130 or DMSO. Data are mean ± S.E. from seven mice in each group. Two-tailed Student's t test was used for statistical analysis (*, p ≤ 0.01m and **, p ≤ 0.002 compared with DMSO). C, boxed plot illustrating the tumor weight following treatment with JI130 or DMSO. Data are mean ± S.D. from seven mice in each group. D, representative pictures of mice treated with JI130 or DMSO. E, transition of body weight of the mice treated with JI130 or DMSO. Data are mean ± S.D. from seven mice in each group.