Figure 3.

Homology models of the α₁ (orange)–γ₂ (green) interface inside the GABA_A receptor in both the GABA-unbound closed state of the channel and the diazepam-bound open state of the channel. These models predict that the nitrogen atom of α₁ lysine 104 (orange residue) and oxygen atom of γ₂ aspartic acid 75 (green residue) are within 9 Å of each other before GABA and diazepam bind (A and enlarged in B) but move to within 5 Å of each other after GABA and diazepam (in red) bind to the receptor (C).