TABLE 1.

Patient characteristics, medications coadministered, and fulfillment of sepsis definition criteria and PRISM^a score on days 1 and 5

Patient no.	Age (yrs)	Sex	Body wt (kg)	Reason(s) for PICU admission	Type(s) of infection	Organism isolated (origin)	Medications coadministered	Day 1		Day 5
								Sepsis criteria met?	PRISM score	Sepsis criteria met?	PRISM score
1	10	M	40	Nontraumatic coma, brain edema, bilateral craniectomy, Bartonella quintana CNSb infection	Febrile skin and soft tissue infection complicating craniectomy	Staphylococcus epidermidis (blood, repeatedly)	Phenytoin, levetiracetam, midazolam, esmolol, enoxaparin sodium, ranitidine, methylprednisolone, piperacillin-tazobactam, gentamicin, rifampin, doxycycline	No	2	No	2
2	8	M	26	Extended (25%) full-thickness burn	Breakthrough sepsis on vancomycin	Enterococcus faecium (blood)	Ranitidine, meropenem, gentamicin, fluconazole	Yes	2	Yes	1
3	9.5	F	45	Rupture of appendix, peritonitis, septic shock	Surgical site infection	Enterococcus faecalis (surgical site, peritoneal fluid)	Remifentanil, propofol, ranitidine, meropenem, amikacin, metronidazole	Yes	7	No	1
4	14	F	45	Acute peritonitis, septic shock	Peritonitis, intra-abdominal abscesses, septic shock		Remifentanil, propofol, ranitidine, noradrenaline, meropenem, metronidazole, micafungin	Yes	7	Yes	1

^aPRISM, pediatric risk of mortality.

^bCNS, central nervous system.